DSkin

DSkin is a software tool to simulate transdermal absorption - or to predict the impenetrability of substances into human skin - for pharmaceutical and cosmetic applications.

Before promising new active substances or cosmetic agents are validated in time-consuming laboratory experiments their concentration-depth profiles can be simulated virtually for various incubation times and amounts applied. This virtual screening step allows to reject substances that do not fit current needs at an early stage of development. Expensive lab tests can be avoided and even the number of employed animal experiment alternatives is reduced.

Furthermore, "playing with parameters" may suggest molecular modifications of the putative active ingredient. Altogether, DSkin has been compiled to meet specific needs for shorter development cycles.

Software and validation
DSkin version 1.3 is the result of more than 6 years of scientific research and development. The intuitive graphical user interface is just a simplification for daily use; the true value is the prediction technique implemented in this software. Our model has been extensively validated in a long process using several substances.

The DSkin approach
One of the main advantages over standard methods is the completely differing technique. Building a mechanistic model is not new in itself. The cutting-edge technique is solving the underlying diffusion equations and implementing these approaches in proprietary software reaching viable runtimes on standard hardware. This mechanistic model promises at least equivalent accuracy to current QSAR models, e.g. the well known Potts-Guy equation, concerning the permeability.
However, where QSAR models are obviously resticted to just one (predicted) parameter (typically permeability) DSkin offers the full range of information you can expect from a penetration/permeation experiment. Due to the mechanistic nature of the model lag-time, steady state flux (infinite dose experiments), change of concentration in the different compartments over time (concentration-depth profiles), compartmental masses, accumulated amount of drug in the acceptor, and more can be computed.

Customization and flexibility
The success of DSkin's convincing results for customer's tasks and specific needs in the past led to the flexible framework of version 1.3. This framework allows for the unique customization of DSkin with additional plugins. As a special service Scientific Consilience offers to adapt and extend DSkin to meet the specific needs of customers.

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Development state and history

2010DSkin 1.0 was released
2011DSkin 1.1 was released
2012DSkin 1.2 was released
2013Rebuilding the underlying software architecture to allow a flexible customization and extension of the standard model
2014 DSkin 1.3 and the first plugin-module DRelease (fitting and simulating formulation release) hit beta state

Several add-on modules for common needs as automated fitting experimental data to the model, handling different release profiles from various vehicles, simulating and predicting the in-vivo situation (including system pharmacokinetics) are currently under development and will be separately purchased as DSkin plugins.

Hardware and software requirements:

  • Modern multicore processor (intel core i5 or better is recommended)
  • At least 2 GB RAM (4 GB is recommended)
  • At least 200 MB of free disk space
  • Windows 7 32/64 bit

Please contact us for a demo version and more information under

DSkin (at) scientific-consilience.com

or use our contact form to get in touch with us right now.